AliousSpurs loaned Spence to Genoa during the January transfer window, including a £10m option to buy.
The Italian club has been impressed with the full-back, valuing his ability to advance up the pitch as a crucial asset.
Although Genoa wants to keep Spence, the £10m price tag poses a challenge.
According to Calciomercato.com, Genoa’s Blazquez is in London to negotiate with Tottenham.
With good relations between the clubs, the Genoa official hopes to reach an agreement to retain Spence in Italy.
Spence made 16 appearances for Genoa, recovering from a disappointing stint at Leeds United in the first half of the season.
Blazquez is striving for a deal, as Spence is currently low in the pecking order under Tottenham manager Ange Postecoglou.
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