The new Tottenham manager must spark an immediate reaction from his squad, with just seven league matches left to steer the club clear of relegation to the Championship.
Having had 10 full days on the training ground ahead of the trip to Sunderland, Roberto De Zerbi will be eager to showcase his preferred system and starting XI at the Stadium of Light.
Reports suggest the Italian could receive a timely double injury boost before his first game in charge of the North London side.
Pape Sarr and Mathys Tel, who both withdrew from international duty due to injuries, are expected to be fit for the clash with Sunderland on April 12. Their potential return would be a welcome boost for De Zerbi, who is also likely to address the broader injury situation during his first press conference as Spurs boss.
There could be further positive news soon, with Mohammed Kudus and Guglielmo Vicario tipped to return in time for the match against Brighton on April 18. Meanwhile, Rodrigo Bentancur is also expected to make his comeback before the end of the month.
However, not all updates are encouraging. James Maddison, who suffered an ACL injury last summer, is not expected back until June, while Wilson Odobert is likely to remain sidelined until November.
Ben Davies, who broke his ankle at West Ham, is not expected to feature again this season, meaning he may have already played his final game for the club.
As for Dejan Kulusevski, there is still no clear timeline for his return, although the forward is reportedly determined to regain full fitness in time for the World Cup.